Ä¢¹½tv

Streamline biomedical product development with advanced computational fluid dynamics analysis

Ä¢¹½tv's biofluid dynamics experts have extensive experience in biomedical and life sciences product development. We can deploy computational fluid dynamics (CFD) within the framework of other computer-aided engineering tools (e.g., reverse engineering/domain definition, multi-physics modeling, additive manufacturing for prototypes, and computer-aided manufacturing and testing) to better understand and/or predict fluid behavior and transport phenomena related to a subject medical device. 

We have used these tools in numerous biomedical and life sciences product development applications, such as: 

• Evaluating the efficacy of designs before prototyping 

• Reducing the volume of in vitro tests with blood and other biological fluids 

• Minimizing the need for preclinical testing 

• Assessing the product function at and beyond the established design boundaries and to elucidate failure mechanisms during root cause analysis 

Blood flow and fluid path analysis

• Hydrodynamics and thermal simulation of cardiac ablation catheters 

• Evaluation of localized shear stress in the fluid path to avoid shear-induced hemolysis 

• Identification of stagnant regions and regions of secondary flow where blood flow that recirculates locally may cause shear-induced trauma, hypoxemia, accumulation of toxic agents, and localized thrombus formation 

Cardiovascular implants

• Assessment of dead zones, hemolysis levels, and pressures on the valve leaves in artificial heart valves and devices (percutaneous (TAVI/TAVR) and surgically placed) 

• Evaluation of cardiovascular and peripheral stents (self-expanding and balloon expanding) 

• Characterization of gas transport efficiency in extracorporeal membrane oxygenation devices 

Flow within containers and devices

• Conducting handling and drainage analysis of flexible containers during use 

• Reconstitution flow and foam generation analysis during the preparation of high-risk pharmaceuticals (oncolytics) or biologics presented in glass vial dose form 

Hemostats, surgical sealants, and glues

• Modeling delivery physics and risks, such as gas embolism in pneumatically assisted spray devices 

• Evaluating sealing capabilities of biomaterials 

Drug delivery systems

• Performance evaluation and optimization of devices including inhalation delivery systems such as propellant-metered dose inhalers, dry powder inhalers, and nebulizers, as well as diffusion-based drug delivery 

Manufacturing and distribution processes

• Evaluating manual and automated filling lines to reduce splashing, foaming, and control of liquid and air-space tolerances, including form-fill-seal environments 

• Modeling of lyophilization process phases